The long-term goal of our research is to deliver foods with health-promoting molecular profiles at low cost to improve the nutrition and health of all Americans. Advances in analytical chemistry are revealing the thousands of unique molecules in food, broadly expanding the number of compounds available in food composition databases. The short-term goals of this current project are to extend our ML models to incorporate the gut microbiome, to provide feedback to molecular breeders of beans, to broaden our diet-molecule-health work to include emerging food molecules, and to identify consumer cost-health trade-offs of dietary choices.